A new spray treating internal blistering, mouth ulcerations and oral scarring is being developed by researchers in the University of Birmingham. Researchers in the University’s Healthcare Technologies Institute and the Institute of Inflammation and Ageing, are working alongside experts in dermatology and dentistry to formulate an oral spray designed for patients with Epidermolysis Bullosa (EB). The research project, funded by DEBRA Ireland and DEBRA UK, aims to alleviate damage to oral linings of the mouth caused by EB.

Blistering to the inside of the mouth, common among those living with EB, makes tasks such as eating, drinking and brushing of the teeth very painful and extremely difficult. Scarring as a result of such blistering, can affect the development of muscles and other tissues.

Over the next two years, the research team, led by Professor Liam Grover, will work alongside clinicians and patient groups on the design of the spray to ensure precise delivery to oral linings of the mouth. The aim of the research is to assess the feasibility of such preparations to be sprayed and to deliver the compound actively to the mouth lining, prior to proceeding to clinical studies.

Professors Adrian Heagerty and Liam Grover explain the project here:

For more detailed information about the project, please visit our website: https://debraireland.org/research/debra-irelands-involvement-in-research/research-studies-treatments-and-cures/a-novel-spray-to-treat-oral-scarring-in-eb/

The first medication specifically developed to treat Epidermolysis Bullosa (EB), has successfully completed a Phase 3 clinical trial.